Set near Port St. Lucie, Florida, the story follows Jolyne Cujoh after her incarceration in Green Dolphin Street Prison. Her father Jotaro soon comes to visit and informs her that a Stand user named Jongalli A, a disciple of Dio's, framed her so that he could kill her in prison, and urges escape. Jolyne's anger at her father, who has been absent for most of her life, is interrupted by a double attack by Jongalli A's Stand, Manhattan Transfer, and another mysterious Stand named White Snake. Fearing for the safety of her father, Jolyne gathers information and friends as she manages her own survival in the prison turned mad-house.

Part 6 of the JoJo's Bizarre Adventure series. Before reading, be sure to have read parts 1 through 5.